Time-lapse: Kinetics and embryo development

Recreating the uterine environment

Embryos from in vitro fertilization develop in an incubator in which the parameters are carefully controlled, in order to recreate the uterine environment as closely as possible.

Until recently, these embryos were generally taken out of the incubator and observed using a microscope once a day to determine their quality and development. These steps must be carried out as quickly as possible to minimize fluctuations in the culture conditions and stress for the embryos.

Observing embryo development

Fertilys recently acquired an incubator with an integrated time-lapse system. With this state-of-the-art technology, the embryos remain in a stable environment and there is no longer any need to remove them from their incubator to observe their continuous development.

This technology makes it possible to:

  • Take pictures of the embryos every 5 to 10 minutes. View the recorded photos, when more information is desired on the development of the embryo.
  • Observe important events in the embryonic development, such as fertilization and cell division.
  • Know the precise time of cell division for each embryo.
  • Compare the kinetic recordings of the development of several embryos to select the dominant one for transfer.
  • Cultivate the embryos of a single patient per incubator chamber. There are six in total.

 

Even though there are no studies that show concrete evidence of an increase in pregnancy rates, the time-lapse system helps us understand considerably better the kinetics of embryo development, as it stabilizes the parameters necessary for their growth (temperature, oxygen, carbon dioxide) in the lab and reduces human error.