Dr Pierre Miron – MD, PhD, FRCSC, Fondateur EGRI (GREI)


International peer-reviewed publications


Founder and President of FERTILYS

Ben-Ami I, Daniel-Spiegel E, Battino S, Molina FS, Melcer Y, Floeck A, Geipel A, Odeh M, Miron P, Maymon R. Do IVF monochorionic twins have a decreased incidence of twin to twin transfusion syndrome? Fertil Steril 2015 Dec 12 (Epub ahead of print)

Ben-Ami I, Daniel-Spiegel E, Battino S, Melcer Y, Floeck A, Geipel A, Miron P, Maymon R. The association of crown-rump length discrepancy with birthweight discordance in spontaneous versus IVF monochorionic twins- a multicenter study. Prenat Diagn 2015 Sep; 35(9): 864-9

Benkhalifa M, Ferreira YJ, Chahine H, Louanjli N, Miron P, Merviel P, Copin H. Mitochondria: Participation to infertility as source of energy and cause of senescence. Int J Biochem Cell Bio 2014 Oct; 55C: 60-64

Miron JP, Cuckle H, Miron P. Prenasal thickness in first-trimester screening for Down syndrome. Prenat Diagn 2012 Jul; 32(7) 695-7

Miron P.  First trimester stepwise sequential prenatal screening test for Down Syndrome using NT and maternal age. Prenat Diagn June 27, 2011

Miron P, Lambert J, Marcil A, Cowans NJ, Stamatopoulou A and Spencer K.. Maternal plasma levels of follistatin-related gene protein in the first trimester of pregnancies with Down syndrome. Prenat Diagn 2010 Mar;30(3):224-8

Miron P, Coté YP, Lambert J. Nuchal translucency thresholds in prenatal screening of Down syndrome and trisomy 18. J Obstet Gynaecol Can. 2009 Mar;31(3):227-35

Miron P, Coté YP, Lambert J. Effect of maternal smoking on prenatal screening for Down syndrome and trisomy 18 in the first trimester of pregnancy. Prenat Diagn. 2008 Feb 8;28(3):180-185 .

A Ali, T Virirak Kattygnarath, M Benkhalifa, P Miron. Essential role of platelet activating factor in male reproduction: a review. Reprod BioMed Online. 2007 Feb: 14(2) 250-5

Ali A, Benkhalifa M and Miron P.  In Vitro Maturation of oocytes: Biological Aspects. Reprod Biomed Online. 2006 Sep;13(3):437-46.

Benkhalifa M, Mercier S, Miron P, Hallahan T, Macrie J, Melançon SB. Implementation of Prenatal screening Program using maternal dried blood. Editions AGPA, ISBN 2-86911-663-3, 2001, 67-75.

Goff AK, Yang Z, Cortvrindt R, Smitz J and Miron P. Protein synthesis during maturation of bovine oocytes, effect of epidermal growth factor. Reprod Domest Anim 2001 Feb;36(1):19-24.

Miron P, Talbot S, Rivard M & Lambert J. « Effectiveness of IVF for Unexplained Infertility and Minimal to Mild Endometriosis-Associated Infertility ». Journal SOGC, February 2001, Volume 23, Number 2, pp. 127-131.

BenKhalifa M, Frydman N, Tachdjian G, Olivennes F, Miron P, Melançon SB, Frydman R, Hamamah S. Diagnostic génétique pré et post-implantatoire par Hybridation in situ multifluorecente et PCR multiplexe : Indications et Troubles Shooting. JTA 2000, 1, 715-721.

Pinheiro R, Bénard F, Mauffette F, Lambert J and Miron P. Effectiveness of ICSI/MESA/PESA for severe male infertility compared to conventional IVF for complete tubal occlusion in women . Canadian Medical Association Journal, November 1999, Volume 161 (11), pp. 1397-1412.

Martin R, Nisker J, Daya S, Miron P and Parish B, Joint Report Canadian Fertility and Andrologie Society  / Society of Obstetricians and Gynaecologists of Canada, Policy Statement Ethical Issues in Assisted Reproduction – Medical and Genetic Screening of Sperm, Oocyte and Embryo Providers. Journal SOGC, May 1999, Volume 21, Number 5, pp 462-466.

Martin R, Nisker J, Daya S, Miron P and Parish B, Joint Report Canadian Fertility and Andrologie Society  / Society of Obstetricians and Gynaecologists of Canada, Policy Statement Ethical Issues in Assisted Reproduction – Social Screening and Reproductive Technologies. Journal SOGC, May 1999, Volume 21, Number 5, pp 456-460.

Gosselin D, Shazand K, Miron P, Lavoie HB, Domin M, Hugo P. “ Insights into the physiopathology of endometriosis – novel diagnostic and therapeutic approchaes “. Current Opinion in Oncologic, Endocrine & Metabolic Investigational Drugs, 1999(1), pp 31-43.

Martin R, Nisker J, Daya S, Miron P and Parish B, Joint Report Canadian Fertility and Andrologie Society  / Society of Obstetricians and Gynaecologists of Canada, Policy Statement Ethical Issues in Assisted Reproduction – Intracytoplasmic Sperm Injection. Journal SOGC, April 1999, Volume 21, Number 4, pp 369-375.

Martin R, Nisker J, Daya S, Miron P and Parish B, Joint Report Canadian Fertility and Andrologie Society  / Society of Obstetricians and Gynaecologists of Canada, Policy Statement Ethical Issues in Assisted Reproduction – Disposition of Frozen Embryos.  Journal SOGC, March 1999, Volume 21, Number 3, pp 275-285.

Martin R, Nisker J, Daya S, Miron P and Parish B, Joint Report Canadian Fertility and Andrologie Society  / Society of Obstetricians and Gynaecologists of Canada, Policy Statement Ethical Issues in Assisted Reproduction – Oocyte Transfer : Sources of Oocytes and the Nature of the Exchange.  Journal SOGC, February 1999, Volume 21, Number 2, pp 175-182.

Martin R, Nisker J, Daya S, Miron P and Parish B, Joint Report Canadian Fertility and Andrologie Society  / Society of Obstetricians and Gynaecologists of Canada, Policy Statement Ethical Issues in Assisted Reproduction – Sperm sorting for Medical and Non-medical Reasons.  Journal SOGC, January 1999, Volume 21, Number 1, pp 67-74.

Martin R, Nisker J, Daya S, Miron P and Parish B, Joint Report Canadian Fertility and Andrologie Society  / Society of Obstetricians and Gynaecologists of Canada, presented to the members of the those comittees on January 1998 and adopted in April 1998.  Journal SOGC, November 1998, Volume 20, Number 13, pp 1235-1241.

Miron P and Lambert J. Letter to the Editor concerning the article published in the Journal SOGC (volume 20 : 139-147, 1998) by Vilos & al « Economic evaluation of in vitro fertilization-embryo transfert (IVF-ET) and neosalpingostomy for bilateral tubal obstruction », Journal SOGC, September 1998, Volume 20, Number 10, pp 927-928.

Miron P, Casper R. “Comparison between HP-FSH and hMG for superovulation in women undergoing in vitro fertilization”. Journal SOGC, March 1998, Volume 20, Number 3, pp 283-288.

Yang Z, St-Jean D, Ward L and Miron P. “Viable pregnancies following transfer of one, two or three ICSI embryos”. Proceedings of the 10th World Congress of In vitro Fertilization and Assisted Reproduction, Monduzzi Editor 1997, p. 841-845.

Yang Z., Miron P, Gu Z, Smitz J, Cortvrindt R, Van Steirteghem A and Goff A. “Two-dimensional analysis of protein synthesis during meiotic maturation of bovine and human oocytes”. Proceedings of the 10th World Congress of In Vitro Fertilization And Assisted Reproduction, Monduzzi Editor 1997, p.349-352.

Yang Z, Miron P and Goff A . “Maturation In vitro of bovine and human oocytes in a chemically defined medium supplemented with EGF”.  Proceedings of the 10th World Congress of In Vitro Fertilization And Assisted Reproduction, Monduzzi Editor 1997, p. 175-178.

Marcoux S, Maheux R, Bérubé S, Miron P and The Canadian Collaborative Group on Endometriosis. “Laparoscopic Surgery in infertile women with minimal or mild endometriosis”.  The New England Journal of Medicine 1997, volume 337, 4:217-222.

Pagidas K, Falcone T, Hemmings R, and Miron P. Abstract from article “Comparison of reoperation for moderate (stage III) and severe (stage IV) endometriosis-related infertility with in vitro fertilization-embryo transfer”, published in Fertility and Sterility 1996, 65:791-5.

OB/GYN DIGEST (Netherlands) 1997

Lachapelle MH, Hemmings R, Roy DC, Falcone T, and  Miron P. Flow-Cytometric Evaluation of Leukocyte Subpopulations in the Folicular Fluids of Infertile Patients. Fertil Steril 1996, 65:1135-40.

Pagidas K, Falcone T, Hemmings R, and Miron P. Comparison of repoeration for moderate (stage III) and severe (stage IV) endometriosis-related infertility with in vitro fertilization-embryo transfer. Fertility and Sterility 1996, 65:791-5.

Lachapelle MH, Miron P, Hemmings R, Roy DC. Endometrial T, B and NK cells in patients with repetitive abortions: Altered profile and pregnancy outcome. J. Immunol 1996, 156:4027-34.

Lachapelle MH, Miron P, Hemmings R, Baron C, Roy DC. Flowcytometric characterization of hematopoietic cells in non pregnant human endometrium. Am J Reprod Immunol 1996, 35:5-13.

Hemmings R, Falcone T, and Miron P. Embryo quality assessment. SOGC Journal 1995, April:372-5.

Hemmings R, and Miron P. Release of Growth Factors by Human Embyros. SOGC Journal, October 1995.

Hemmings R, Lachapelle MH, Falcone T, Miron P, Ward L, Guyda H. Effect of follicular fluid supplementation on the in vitro development of human pre-embryos.  Fertil Steril 1994, 62:1018-21.

Pagidas K, Hemmings R, Falcone T, and Miron P. The effect of antisperm autoantibodies in male or female partners undergoing in vitro fertilization – embryo transfer. Fertil Steril 1994, 62:363-69.

Lachapelle MH, Bouzayen R, Langlais J, Jarvi K., Bourque J, and Miron P. Effect of lysoplatelet-activating factor on human sperm fertilizing hability. Fertil Steril 1993, 59:863-68.

Lachapelle MH, Miron P, Hemmings R, Falcone T, Granger L, Bourque J, Perreault C, Langlais J. Embryonic resistance to tumour necrosis factor-? mediated cytotoxicity: novel mechanism underlying maternal immunological tolerance to the fetal allograft. Human Reprod 1993, 8:1032-38.

Lepage N, Miron P, Hemmings R, Roberts KD, Langlais J. Distribution of lysophospholipids and metabolism of platelet-activating factor in human follicular and peritoneal fluids. J Reprod Fertil 1993, 98:349-56.

Falcone T, Miron P, Granger L, Bourque J, Hemmings R.  Polycystic ovarian syndrome. Current problems in Obstet and Gynecol 1993, XVI:65-95.

Hemmings R, Miron P, Falcone T, Bourque J, Lepage N, Langlais J. Platelet activating factor acetylhydrolase activity and peritoneal fluid of women with endometriosis. Obstet Gynecol 1993, 81;276-9.

Hamanah S, Royere D, Miron P, Nicolle JC, Lansac J. Human sperm chromatin alterations after freezing-thawing and in vitro fertilization. In: Comparative spermatology 20 years after. Ed. B. Bacette, Serono Symposia Publications, Ravin Press 75, 1101 pp 899-903, 1992.

Tulandi T, Miron P, Leung P, Jarrel J. Oocyte donation: a proposed guideline of the Canadian fertility and Andrology Society. SOGC Journal, 1992.

Miron P, Dizazzo A, Auger E, St-Michel P, Faucher G, Langlais J, Granger L.  Évaluation de la phase lutéale selon quatre méthodes diagnostiques de l’ovulation.  SOGC Journal, 1992.

Hemmings R, Langlais J, Falcone T, Bourque J, Granger L, Miron P, Guyda H. Human embryos produce transforming growth factors ? and insulin like growth factors II. Fertil Steril 58:101, 1992.

Letendre ED, Roberts KD, Miron P, Langlais J. Platelet-activating factor acetylhydrolase activity in human semen. Fertil Steril 47:193, 1992.

Royere D, Hamamah S, Miron P, Nicolle JC, Lansac J. Relations entre les altérations chromatiniennes lors de la congélation du sperme humain et les événements précoces de la fécondation in vitro. Fertil Contracep Sexualité, 18:532, 1990.

Miron P, Hay DL, Johnston I, McKenna M, McBain JD. Midcycle changes of 17-OH-Progesterone levels in women superovulated with Clomiphene Citrate and hMG for in vitro fertilization. Fertil Steril 49:843, 1988.

Taylor P, Miron P, Livingston R, Jarrell J. In vitro fertilization: concepts and controversies. Symposium. Contemporary Ob/Gyn 5:30, 1988.

Miron P, Lemieux MC, Granger L et al. Association of ureaplasma urealyticum and sperm antibodies in cervical mucus. Fertil Steril 42:169, 1984.

General interest Health Science Book

Miron P, Provençal M, Gingras D. Concevoir. Prévenir et traiter l’infertilité. (2013) Éditions du Trécarré (Groupe Librex). In French

Miron P, Provençal M, Gingras D. Conceiving. Preventing and treating infertility (2015). Editor: Dundurn ISBN : 9781459730076. In English

Miron P, Provençal M, Gingras D. Conceiving. Preventing and treating infertility (2015). In Chinese

Miron P, Provençal M, Gingras D. Conceiving. Preventing and treating infertility (2016). In Malayalam (India)


Moncef Benkhalifa – PhD

International peer-reviewed publications


Founder and Scientific VP of FERTILYS

Marouani N, Tebourbi O, Hallègue D, Mokni M, Yacoubi MT, Sakly M, Benkhalifa M, Rhouma KB. Mechanisms of chromium hexavalent-induced apoptosis in testis rats. Toxicol Ind Health. 2015 Sep 29. pii: 0748233715600333. [Epub ahead of print]

Okutman O, Muller J, Baert Y, Serdarogullari M, Gultomruk M, Piton A, Rombaut C, Benkhalifa M, Teletin M, Skory V, Bakircioglu E, Goossens E, Bahceci M, Viville S. Exome sequencing reveals a nonsense mutation in TEX15 causing spermatogenic failure in a Turkish family. Hum Mol Genet. 2015 Oct 1;24(19):5581-8.

Kaarouch I, Bouamoud N, Louanjli N, Madkour A, Copin H, Benkhalifa M, Sefrioui O. Impact of sperm genome decay on Day-3 embryo chromosomal abnormalities from advanced-maternal-age patients. Mol Reprod Dev. 2015 Oct;82(10):809-19.

Benkhalifa M, Madkour A, Louanjli N, Bouamoud N, Saadani B, Kaarouch I, Chahine H, Sefrioui O, Merviel P, Copin H. From global proteome profiling to single targeted molecules of follicular fluid and oocyte: contribution to embryo development and IVF outcome. Expert Rev Proteomics. 2015 Aug;12(4):407-23.

Jedraszak G, Copin H, Demailly M, Quibel C, Leclerc T, Gallet M, Benkhalifa M, Receveur A.  Azoospermia and trisomy 18p syndrome: a fortuitous association? A patient report and a review of the literature. Mol Cytogenet. 2015 Jun 4;8:34.

Merviel P, Cabry-Goubet R, Lourdel E, Devaux A, Belhadri-Mansouri N, Copin H, Benkhalifa M. Comparative prospective study of 2 ovarian stimulation protocols in poor responders: effect on implantation rate and ongoing pregnancy. Reprod Health. 2015 May 30;12:52.

Montjean D, Zini A, Ravel C, Belloc S, Dalleac A, Copin H, Boyer P, McElreavey K, Benkhalifa M. Sperm global DNA methylation level: association with semen parameters and genome integrity. Andrology. 2015 Mar;3(2):235-40

Makrigiannakis A, BenKhalifa M, Vrekoussis T, Mahjub S, Kalantaridou SN, Gurgan T. Repeated implantation failure: a new potential treatment option. Eur J Clin Invest. 2015 Apr;45(4):380-4.

Madkour A,Bouamoud N, Louanjli N, Kaarouch I, Copin H, Benkhalifa M, Sefrioui O. Intrauterine insemination of cultured peripheral blood mononuclear cells prior to embryo transfer improves clinical outcome for patients with repeated implantation failures. Zygote. 2016 Feb;24(1):58-69.

Cabry-Goubet R, Lombart M, Scheffler-Garhieni F, Lourdel E, Carette F, Devaux A, Copin H, Benkhalifa M, Merviel P. [Are patients in the postpartum period potential egg donors?]. Gynecol Obstet Fertil. 2014 Dec;42(12):844-8.

Belloc S, Cohen-Bacrie M, Amar E, Izard V, Benkhalifa M, Dalléac A, de Mouzon J. High body mass index has a deleterious effect on semen parameters except morphology: results from a large cohort study. Fertil Steril. 2014 Nov;102(5):1268-73.

Benkhalifa M, Ferreira YJ, Chahine H, Louanjli N, Miron P, Merviel P, Copin H. Mitochondria: participation to infertility as source of energy and cause of senescence. Int J Biochem Cell Biol. 2014 Oct;55:60-4.

Marouani N, Tebourbi O, Mokni M, Yacoubi MT, Sakly M, Benkhalifa M, Rhouma KB. Hexavalent Chromium-Induced Apoptosis in Rat Uterus: Involvement of Oxidative Stress. Arch Environ Occup Health. 2015;70(4):189-95.

Belloc S, Benkhalifa M, Cohen-Bacrie M, Dalleac A, Amar E, Zini A. Sperm deoxyribonucleic acid damage in normozoospermic men is related to age and sperm progressive motility. Fertil Steril. 2014 Jun;101(6):1588-93.

Belloc S, Hazout A, Zini A, Merviel P, Cabry R, Chahine H, Copin H, Benkhalifa M. How to overcome male infertility after 40: Influence of paternal age on fertility. Maturitas. 2014 May;78(1):22-9.

Cabry R, Merviel P, Hazout A, Belloc S, Dalleac A, Copin H, Benkhalifa M. Management of infertility in women over 40. Maturitas. 2014 May;78(1):17-21.

Merviel P, Cabry R, Lourdel E, Barbier F, Scheffler F, Mansouri N, Devaux A, Benkhalifa M, Copin H. [Intrauterine insemination]. Rev Prat. 2014 Jan;64(1):87-91. Review. French.

Belloc S, Benkhalifa M, Cohen-Bacrie M, Dalleac A, Chahine H, Amar E, Zini A. Which isolated sperm abnormality is most related to sperm DNA damage in men presenting for infertility evaluation. J Assist Reprod Genet. 2014 May;31(5):527-32.

Emerging molecular methods for male infertility investigation.

Benkhalifa M, Montjean D, Belloc S, Dalleac A, Ducasse M, Boyer P, Merviel P, Copin H.

Expert Rev Mol Diagn. 2014 Jan;14(1):37-45.

Montjean D, Ravel C, Benkhalifa M, Cohen-Bacrie P, Berthaut I, Bashamboo A, McElreavey K. Methylation changes in mature sperm deoxyribonucleic acid from oligozoospermic men: assessment of genetic variants and assisted reproductive technology outcome. Fertil Steril. 2013 Nov;100(5):1241-7.

Marouani N, Tebourbi O, Mahjoub S, Yacoubi MT, Sakly M, Benkhalifa M, Rhouma KB. Effects of hexavalent chromium on reproductive functions of male adult rats. Reprod Biol. 2012 Jul;12(2):119-33.

Montjean D, Belloc S, Benkhalifa M, Dalleac A, Ménézo Y. Sperm vacuoles are linked to capacitation and acrosomal status.Hum Reprod. 2012 Oct;27(10):2927-32.

Benkhalifa M, Montjean D, Hatem B. [Preimplantation genetic diagnosis embryo screening before intra-uterine transfer is useful]. Gynecol Obstet Fertil. 2012 Jul-Aug;40(7-8):449-51.

Elinati E, Kuentz P, Redin C, Jaber S, Vanden Meerschaut F, Makarian J, Koscinski I, Nasr-Esfahani MH, Demirol A, Gurgan T, Louanjli N, Iqbal N, Bisharah M, Pigeon FC, Gourabi H, De Briel D, Brugnon F, Gitlin SA, Grillo JM, Ghaedi K, Deemeh MR, Tanhaei S, Modarres P, Heindryckx B, Benkhalifa M, Nikiforaki D, Oehninger SC, De Sutter P, Muller J, Viville S. Globozoospermia is mainly due to DPY19L2 deletion via non-allelic homologous recombination involving two recombination hotspots. Hum Mol Genet. 2012 Aug 15;21(16):3695-702.

Junca A, Gonzalez Marti B, Tosti E, Cohen M, De la Fontaine D, Benkhalifa M, Ménézo Y. Sperm nucleus decondensation, hyaluronic acid (HA) binding and oocyte activation capacity: different markers of sperm immaturity? Case reports. J Assist Reprod Genet. 2012 Apr;29(4):353-5.

Montjean D, De La Grange P, Gentien D, Rapinat A, Belloc S, Cohen-Bacrie P, Menezo Y, Benkhalifa M. Sperm transcriptome profiling in oligozoospermia. J Assist Reprod Genet. 2012 Jan;29(1):3-10.

Gurgan T, Demirol A, Guven S, Benkhalifa M, Girgin B, Li TC. Intravenous calcium infusion as a novel preventive therapy of ovarian hyperstimulation syndrome for patients with polycystic ovarian syndrome. Fertil Steril. 2011 Jul;96(1):53-7.

Ménézo Y, Pluntz L, Chouteau J, Gurgan T, Demirol A, Dalleac A, Benkhalifa M. Zinc concentrations in serum and follicular fluid during ovarian stimulation and expression of Zn2+ transporters in human oocytes and cumulus cells. Reprod Biomed Online. 2011 Jun;22(6):647-52.

Benkhalifa M, Demirol A, Sari T, Balashova E, Tsouroupaki M, Giakoumakis Y, Gurgan T. Autologous embryo-cumulus cells co-culture and blastocyst transfer in repeated implantation failures: a collaborative prospective randomized study. Zygote. 2012 May;20(2):173-80.

Marouani N, Tebourbi O, Mokni M, Yacoubi MT, Sakly M, Benkhalifa M, Ben Rhouma K. Embryotoxicity and fetotoxicity following intraperitoneal administrations of hexavalent chromium to pregnant rats. Zygote. 2011 Aug;19(3):229-35.

Montjean D, Benkhalifa M, Dessolle L, Cohen-Bacrie P, Belloc S, Siffroi JP, Ravel C, Bashamboo A, McElreavey K. Polymorphisms in MTHFR and MTRR genes associated with blood plasma homocysteine concentration and sperm counts. Fertil Steril. 2011 Feb;95(2):635-40.

Demirol A, Guven S, Benkhalifa M, Sari T, Gurgan T. Successful birth following transfer of frozen-thawed embryos produced from in-vitro matured oocytes. Reprod Biomed Online. 2010 Aug;21(2):215-8.

Menezo Y, Elder K, Benkhalifa M, Dale B. DNA methylation and gene expression in IVF. Reprod Biomed Online. 2010 Jun;20(6):709-10.

Montjean D, Ménézo Y, Benkhalifa M, Cohen M, Belloc S, Cohen-Bacrie P, de Mouzon J. Malonaldehyde formation and DNA fragmentation: two independent sperm decays linked to reactive oxygen species. Zygote. 2010 Aug;18(3):265-8.

Belloc S, Benkhalifa M, Junca AM, Dumont M, Bacrie PC, Ménézo Y. Paternal age and sperm DNA decay: discrepancy between chromomycin and aniline blue staining. Reprod Biomed Online. 2009 Aug;19(2):264-9..

Benkhalifa M, Montjean D, Cohen-Bacrie P, Ménézo Y. Imprinting: RNA expression for homocysteine recycling in the human oocyte. Fertil Steril. 2010 Mar 15;93(5):1585-90.

Benkhalifa M, Demirol A, Ménézo Y, Balashova E, Abduljalil AK, Abbas S, Giakoumakis I, Gurgan T. Natural cycle IVF and oocyte in-vitro maturation in polycystic ovary syndrome: a collaborative prospective study. Reprod Biomed Online. 2009 Jan;18(1):29-36.

Kasakyan S, Lohmann L, Aboura A, Quimsiyeh M, Menezo Y, Tachdjian G, Benkhalifa M. De novo complex intra chromosomal rearrangement after ICSI: characterisation by BACs micro array-CGH. Mol Cytogenet. 2008 Dec 23;1:27.

Belloc S, Cohen-Bacrie P, Benkhalifa M, Cohen-Bacrie M, De Mouzon J, Hazout A, Ménézo Y. Effect of maternal and paternal age on pregnancy and miscarriage rates after intrauterine insemination. Reprod Biomed Online. 2008 Sep;17(3):392-7.

Caserta D, Benkhalifa M, Baldi M, Fiorentino F, Qumsiyeh M, Moscarini M. Genome profiling of ovarian adenocarcinomas using pangenomic BACs microarray comparative genomic hybridization. Mol Cytogenet. 2008 May 20;1:10.

Cohen-Bacrie P, Belloc S, Ménézo YJ, Clement P, Hamidi J, Benkhalifa M. Correlation between DNA damage and sperm parameters: a prospective study of 1,633 patients. Fertil Steril. 2009 May;91(5):1801-5.

Tachdjian G, Aboura A, Portnoï MF, Pasquier M, Bourcigaux N, Simon T, Rousseau G, Finkel L, Benkhalifa M, Christin-Maitre S. Cryptic Xp duplication including the SHOX gene in a woman with 46,X, del(X)(q21.31) and premature ovarian failure. Hum Reprod. 2008 Jan;23(1):222-6.

Menezo Y Jr, Russo G, Tosti E, El Mouatassim S, Benkhalifa M. Expression profile of genes coding for DNA repair in human oocytes using pangenomic microarrays, with a special focus on ROS linked decays. J Assist Reprod Genet. 2007 Nov;24(11):513-20.

Ménézo YJ, Hazout A, Panteix G, Robert F, Rollet J, Cohen-Bacrie P, Chapuis F, Clément P, Benkhalifa M. Antioxidants to reduce sperm DNA fragmentation: an unexpected adverse effect. Reprod Biomed Online. 2007 Apr;14(4):418-21.

Delahaye A, Pipiras E, Kanafani S, Touboul C, Vergnaud A, Encha-Razavi F, Sinico M, Benkhalifa M, Kasakyan S, Serero S, Wolf JP, Gérard-Blanluet M, Benzacken B. De novo subtelomeric deletion additional to an inherited apparently balanced reciprocal translocation. Fetal Diagn Ther. 2007;22(4):306-12.

Ali A, Virirak Kattygnarath T, Benkhalifa MB, Miron P. Essential role of platelet-activating factor in male reproduction: a review. Reprod Biomed Online. 2007 Feb;14(2):250-5. Review.

Ali A, Benkhalifa M, Miron P. In-vitro maturation of oocytes: biological aspects. Reprod Biomed Online. 2006 Sep;13(3):437-46. Review.

Delahaye A, Pipiras E, Delorme-Vincent C, Benkhalifa M, Kasakyan S, Devisme L, Wolf JP, Benzacken B. Retrospective diagnosis of Pallister-Killian syndrome by CGH array. Fetal Diagn Ther. 2006;21(6):485-8.

Demirol A, Benkhalifa M, Sari T, Gurgan T. Use of laser-assisted intracytoplasmic sperm injection (ICSI) in patients with a history of poor ICSI outcome and limited metaphase II oocytes. Fertil Steril. 2006 Jul;86(1):256-8.

Brisset S, Kasakyan S, L’Herminé AC, Mairovitz V, Gautier E, Aubry MC, Benkhalifa M, Tachdjian G. De novo monosomy 9p24.3-pter and trisomy 17q24.3-qter characterised by microarray comparative genomic hybridisation in a fetus with an increased nuchal translucency. Prenat Diagn. 2006 Mar;26(3):206-13.

Benkhalifa M, Kasakyan S, Clement P, Baldi M, Tachdjian G, Demirol A, Gurgan T, Fiorentino F, Mohammed M, Qumsiyeh MB. Array comparative genomic hybridization profiling of first-trimester spontaneous abortions that fail to grow in vitro. Prenat Diagn. 2005 Oct;25(10):894-900.

Petit FM, Frydman N, Benkhalifa M, Le Du A, Aboura A, Fanchin R, Frydman R, Tachdjian G. Could sperm aneuploidy rate determination be used as a predictive test before intracytoplasmic sperm injection? J Androl. 2005 Mar-Apr;26(2):235-41.

Tachdjian G, Aboura A, Benkhalifa M, Creveaux I, Foix-Hélias L, Gadisseux JF, Boespflug-Tanguy O, Mohammed M, Labrune P. De novo interstitial direct duplication of Xq21.1q25 associated with skewed X-inactivation pattern. Am J Med Genet A. 2004 Dec 15;131(3):273-80.

Hellani A, Coskun S, Benkhalifa M, Tbakhi A, Sakati N, Al-Odaib A, Ozand P. Multiple displacement amplification on single cell and possible PGD applications. Mol Hum Reprod. 2004 Nov;10(11):847-52. Epub 2004 Oct 1.

Benkhalifa M, Kahraman S, Biricik A, Serteyl S, Domez E, Kumtepe Y, Qumsiyeh MB. Cytogenetic abnormalities and the failure of development after round spermatid injections.Fertil Steril. 2004 May;81(5):1283-8.

Kahraman S, Benkhalifa M, Donmez E, Biricik A, Sertyel S, Findikli N, Berkil H. The results of aneuploidy screening in 276 couples undergoing assisted reproductive techniques. Prenat Diagn. 2004 Apr;24(4):307-11.

Lapierre JM, Sanlaville D, Kang J, Ozilou C, Le Lorc’h M, Waill MC, Prieur M, Colleaux L, Munnich A, Turleau C, Benkhalifa M, Mohammed M, Vekemans M, Romana S. [A preliminary study to assess the value of the DNA chips SpectralChip to detect subtle constitutional chromosome imbalances]. Ann Biol Clin (Paris). 2004 Mar-Apr;62(2):203-12. French.

Findikli N, Kahraman S, Kumtepe Y, Donmez E, Benkhalifa M, Biricik A, Sertyel S, Berkil H, Oncu N. Assessment of DNA fragmentation and aneuploidy on poor quality human embryos. Reprod Biomed Online. 2004 Feb;8(2):196-206.

Benkhalifa M, Kahraman S, Caserta D, Domez E, Qumsiyeh MB. Morphological and cytogenetic analysis of intact oocytes and blocked zygotes. Prenat Diagn. 2003 May;23(5):397-404.

Kahraman S, Kumtepe Y, Sertyel S, Dönmez E, Benkhalifa M, Findikli N, Vanderzwalmen P. Pronuclear morphology scoring and chromosomal status of embryos in severe male infertility. Hum Reprod. 2002 Dec;17(12):3193-200.

Curotti G, Benkhalifa M, Raybaud C, Picard F, Bellec V, Qumsiyeh MB. De novo highly complex chromosome rearrangement (CCR) involving five breakpoints with congenital anomalies analyzed by FISH. Genet Couns. 1999;10(3):259-64.

Ménézo Y, Veiga A, Benkhalifa M. Improved methods for blastocyst formation and culture. Hum Reprod. 1998 Dec;13 Suppl 4:256-65. Review.

Veiga A, Sandalinas M, Benkhalifa M, Boada M, Carrera M, Santaló J, Barri PN, Ménézo Y. Laser blastocyst biopsy for preimplantation diagnosis in the human. Zygote. 1997 Nov;5(4):351-4.

Ménézo YJ, Bellec V, Zaroukian A, Benkhalifa M. Embryo selection by IVF, co-culture and transfer at the blastocyst stage in case of translocation. Hum Reprod. 1997 Dec;12(12):2802-3.

Viniou N, Abazis D, Yataganas X, Benkhalifa M, Stamatopoulos K, Vayopoulos G, Plata E, Loukopoulos D, Pangalos C. A novel chromosomal abnormality involving chromosomes 2 and 18 in a patient with myelodysplastic syndrome. Cancer Genet Cytogenet. 1997 Jul 1;96(1):7-12.

Delon B, Lallaoui H, Abel-Lablanche C, Geneix A, Bellec V, Benkhalifa M. Fluorescent in-situ hybridization and sequence-tagged sites for delineation of an X:Y translocation in a patient with secondary amenorrhoea. Mol Hum Reprod. 1997 May;3(5):439-43.

Mendoza C, Benkhalifa M, Cohen-Bacrie P, Hazout A, Ménézo Y, Tesarik J. Combined use of proacrosin immunocytochemistry and autosomal DNA in situ hybridisation for evaluation of human ejaculated germ cells. Zygote. 1996 Nov;4(4):279-83.

Benkhalifa M, Menezo Y, Janny L, Pouly JL, Qumsiyeh MB. Cytogenetics of uncleaved oocytes and arrested zygotes in IVF programs. J Assist Reprod Genet. 1996 Feb;13(2):140-8.

Johnson DW, Qumsiyeh M, Benkhalifa M, Marchuk DA. Assignment of human transforming growth factor-beta type I and type III receptor genes (TGFBR1 and TGFBR3) to 9q33-q34 and 1p32-p33, respectively. Genomics. 1995 Jul 20;28(2):356-7.

Taiar N, Qumsiyeh MB, Croteau S, Rollet J, Benkhalifa M. Detection of t(X;Y) in 2 XX males using fluorescent in situ hybridization. Ann Genet. 1995;38(2):102-5.

Wang MR, Perissel B, Taillandier J, Kémény JL, Fonck Y, Lautier A, Benkhalifa M, Malet P. Nonrandom changes of chromosome 10 in bladder cancer. Detection by FISH to interphase nuclei. Cancer Genet Cytogenet. 1994 Mar;73(1):8-10.

Benkhalifa M, Janny L, Vye P, Malet P, Boucher D, Menezo Y. Assessment of polyploidy in human morulae and blastocysts using co-culture and fluorescent in-situ hybridization. Hum Reprod. 1993 Jun;8(6):895-902.

Perissel B, Benkhalifa M, Taillandier J, Dastugue N, Haus O, Charbonné F, Giraud B, Malet P. Karyotype and FISH analysis of a newly established cell line derived from a human bladder carcinoma. Cancer Genet Cytogenet. 1993 Jun;67(2):101-7.

Malet P, Benkhalifa M, Perissel B, Geneix A, Le Corvaisier B. Chromosome analysis by image processing in a computerized environment. Clinical applications. J Radiat Res. 1992 Mar;33 Suppl:171-88. Review.

Benkhalifa M, Bonneau M, Popescu P, Boscher J, Boucher D, Malet P. A method for cytogenetic analysis of boar spermatozoa using hamster oocytes. Ann Genet. 1992;35(1):61-4.



S_Antes04-640x960Ates S, Tulandi T. Malpractice claims and avoidance of complications in endoscopic surgery, in Best Practice & Research: Clinical Obstetrics & Gynaecology, Elsevier, 2013 Jun;27(3):349-61.

Shrim A, Ates S, Mallozzi A, Brown R, Ponette V, Levin I, Shehata F, Almog B.  Is young maternal age really a risk factor for adverse pregnancy outcome in a Canadian tertiary referral hospital? J Pediatr Adolesc Gynecol. 2011 Aug;24(4):218-22.

Buckett W, Ates S. Obstetric, neonatal, and infant outcomes following assisted reproduction, in Studd J, Tan SL, Chervenak F, ed., Current Progress in Obstetrics and Gynecology, Volume-1, Tree Life Media, Mumbai, 2012: 98-117.


Gaël Cagnone, PhD Embryologist

International peer-reviewed publications


Gael Cagnone 2Johnson J, Lee W, Frazier AE, Vaghjiani V, Laskowski A, Rodriguez AL, Cagnone G, McKenzie M, White SJ, Nisbet DR, Thorburn DR, St John J. Deletion of the complex I subunit NDUFS4 adversely modulates cellular differentiation. Stem Cells Dev. 2015 Nov 26.

Lee W, Johnson J, Gough DJ, Donoghue J, Cagnone GL, Vaghjiani V, Brown KA, Johns TG, St John JC. Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny Cell Death Dis. 2015 Feb 26.

Scantland S, Tessaro I, Macabelli CH, Macaulay AD, Cagnone G, Fournier E, Luciano AM, Robert C. The adenosine salvage pathway as an alternative to mitochondrial production of ATP in maturing mammalian oocytes. Biol Reprod. 2014 Jul 30.

Cagnone GL, Sirard MA. The impact of exposure to serum lipids during in vitro culture on the transcriptome of bovine blastocysts. Theriogenology 2013 Dec 19. Volume 81, Issue 5, Pages 712–722.

Cagnone GL, Sirard MA. Transcriptomic signature to oxidative stress exposure at the time of embryonic genome activation in bovine blastocysts. Mol Reprod Dev. 2013 Apr 5; 80(4):297-314.

Cagnone GL, Dufort I, Vigneault C, Sirard MA. Differential Gene Expression Profile in Bovine Blastocysts Resulting from Hyperglycemia Exposure During Early Cleavage Stages. Biol Reprod. 2012 Feb 29;86(2):50.

Robert, C., Nieminen, J., Dufort, I., Gagne, D., Grant, J. R., Cagnone, GL., Plourde, D., Nivet, A. L., Fournier, E., Paquet, E., Blazejczyk, M., Rigault, P., Juge, N., Sirard, M. A. Combining resources to obtain a comprehensive survey of the bovine embryo transcriptome through deep sequencing and microarrays. Mol Reprod Dev. 2011 Sep 78(9):651-64.

Book Chapter

Lee W, Kelly RD, Yeung KY, Cagnone G, McKenzie M, John JC. Analysis of mitochondrial DNA in induced pluripotent and embryonic stem cells. Methods Mol Biol. 2015;1330:219-52.

Gael Cagnone, Vijesh Vaghjiani, William Lee, Claire Sun, Ka Yu Yeung, Justin C. St. John. Analysis of the mitochondrial DNA and its replicative capacity in induced pluripotent stem cells. Methods in Molecular Biology, 2015 Feb 3.

Luis Baldoceda, PhD Embryologiste

International peer-reviewed publications

Baldoceda L, Gagné D, Ferreira CR, Robert C. Genetic influence on the reduction in bovine embryo lipid content by l-carnitine. Reprod Fertil Dev. 2015 Jan 9. doi: 10.1071/RD14215. [Epub ahead of print]

Baldoceda L, Gilbert I, Gagné D, Vigneault C, Blondin P, Ferreira CR, Robert C. Breed-specific factors influence embryonic lipid composition: comparison between Jersey and Holstein. Reprod Fertil Dev. 2015 Jan 15. doi: 10.1071/RD14211. [Epub ahead of print]